LAMB2 - Laminin subunit beta-2 - human protein (Function)
 
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LAMB2 »  Laminin subunit beta-2
 
Protein also known as:  Laminin-15 subunit beta.
Gene name:  LAMB2
Entry whose protein(s) existence is based on evidence at protein level
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1 57 1
GENE REF ISO

Function

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Overview 
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.  
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Structural molecule activitydefinition[GO:0005198]  
1
  • NASPINC
GO biological process 
Astrocyte developmentdefinition[GO:0014002] silver  
  • IEAOrtholog Compara
Axon extension involved in regenerationdefinition[GO:0048677] silver  
  • IEAOrtholog Compara
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Metanephric glomerular basement membrane developmentdefinition[GO:0072274] silver  
  • IEAOrtholog Compara
Metanephric glomerular visceral epithelial cell developmentdefinition[GO:0072249] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Schwann cell developmentdefinition[GO:0014044] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+3913  
ECM-receptor interaction  hsa04512+3913  
Focal adhesion  hsa04510+3913  
Pathways in cancer  hsa05200+3913  
Small cell lung cancer  hsa05222+3913  
Toxoplasmosis  hsa05145+3913  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Laminin,_beta_2
GenomeRNAi: 3913
PRO: PR:P55268