CDKN2D - Cyclin-dependent kinase 4 inhibitor D - human protein (Function)
 
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CDKN2D »  Cyclin-dependent kinase 4 inhibitor D
 
Protein also known as:  p19-INK4d.
Gene name:  CDKN2D
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Interacts strongly with CDK4 and CDK6 and inhibits them.  
2
  • CuratedUniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
GO biological process 
Autophagic cell deathdefinition[GO:0048102]  
1
  • IMPBHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDABHF-UCL
DNA synthesis involved in DNA repairdefinition[GO:0000731]  
1
  • IMPBHF-UCL
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IDABHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IMPBHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • IMPBHF-UCL
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDABHF-UCL
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
1
  • IDAGOC
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • IDABHF-UCL
Response to retinoic aciddefinition[GO:0032526]  
1
  • IMPBHF-UCL
Response to UVdefinition[GO:0009411]  
1
  • IMPBHF-UCL
Response to vitamin Ddefinition[GO:0033280]  
1
  • IMPBHF-UCL
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell cycle  hsa04110+1032  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDKN2D
GenomeRNAi: 1032
PRO: PR:P55273