CDH13 - Cadherin-13 - human protein (Function)
 
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Protein
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CDH13 »  Cadherin-13
 
Protein also known as:  Truncated cadherin (T-cad).
Gene name:  CDH13
Entry whose protein(s) existence is based on evidence at protein level
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1 105 5
GENE REF ISO

Function

 show evidences
Overview 
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.  
1
  • CuratedUniProtKB
GO molecular function 
Adiponectin bindingdefinition[GO:0055100]  
  • ISSOrtholog Curator
Cadherin bindingdefinition[GO:0045296]  
1
  • IDABHF-UCL
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Lipoprotein particle bindingdefinition[GO:0071813]  
1
  • IDAUniProtKB
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
1
  • IDABHF-UCL
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Calcium-dependent cell-cell adhesiondefinition[GO:0016339]  
1
  • IDABHF-UCL
Endothelial cell migrationdefinition[GO:0043542]  
1
  • IDABHF-UCL
Homophilic cell adhesiondefinition[GO:0007156]  
1
  • IDABHF-UCL
Keratinocyte proliferationdefinition[GO:0043616]  
1
  • IDABHF-UCL
Lamellipodium assemblydefinition[GO:0030032]  
1
  • IDABHF-UCL
Localization within membranedefinition[GO:0051668]  
1
  • IMPBHF-UCL
Low-density lipoprotein particle mediated signalingdefinition[GO:0055096]  
1
  • IDABHF-UCL
Mitotic cell cycledefinition[GO:0000278] silver  
  • IEAOrtholog Compara
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Positive regulation of calcium-mediated signalingdefinition[GO:0050850]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • IMPBHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IMPBHF-UCL
Positive regulation of positive chemotaxisdefinition[GO:0050927]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Rac protein signal transductiondefinition[GO:0016601]  
1
  • IMPBHF-UCL
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAOrtholog Compara
Regulation of endocytosisdefinition[GO:0030100]  
1
  • IMPBHF-UCL
Regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042058]  
1
  • IMPBHF-UCL
Rho protein signal transductiondefinition[GO:0007266]  
1
  • IMPBHF-UCL
Sprouting angiogenesisdefinition[GO:0002040]  
1
  • IDABHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: T-cadherin
GenomeRNAi: 1012
PRO: PR:P55290