FOXG1 - Forkhead box protein G1 - human protein (Function)
 
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Protein
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FOXG1 »  Forkhead box protein G1
 
Protein also known as:  Forkhead-related protein FKHL1 (HFK1).
Gene name:  FOXG1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Axon midline choice point recognitiondefinition[GO:0016199] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420]  
2
  • TASPINC
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Neuron fate determinationdefinition[GO:0048664] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
  • IEAOrtholog Compara
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
  • IEAOrtholog Compara
Pyramidal neuron migrationdefinition[GO:0021852] silver  
  • IEAOrtholog Compara
Regulation of mitotic cell cycledefinition[GO:0007346] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Caution 
PubMed7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXG1
GenomeRNAi: 2290
PRO: PR:P55316