FOXG1 - Forkhead box protein G1 - human protein (Function)
 
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FOXG1 »  Forkhead box protein G1
 
Protein also known as:  Forkhead-related protein FKHL3 (HFK3).
Gene name:  FOXG1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.  
2
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Axon midline choice point recognitiondefinition[GO:0016199] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420]  
2
  • PINC
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neuron fate determinationdefinition[GO:0048664] silver  
1
  • Ortholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
1
  • Ortholog Compara
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Pyramidal neuron migrationdefinition[GO:0021852] silver  
1
  • Ortholog Compara
Regulation of mitotic cell cycledefinition[GO:0007346] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Caution 
PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXG1
GenomeRNAi: 2290
PRO: PR:P55316