FOXA3 - Hepatocyte nuclear factor 3-gamma - human protein (Function)
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FOXA3 »  Hepatocyte nuclear factor 3-gamma  (HNF-3G)
Protein also known as:  Fork head-related protein FKH H3.
Gene name:  FOXA3
Entry whose protein(s) existence is based on evidence at protein level
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Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.  
  • CuratedUniProtKB
GO molecular function 
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAInterPro 2 GO
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IBARefGenome
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134] silver  
  • IBARefGenome
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • IMPUniProtKB
GO biological process 
Cellular glucose homeostasisdefinition[GO:0001678]  
  • TASUniProtKB
Cellular response to starvationdefinition[GO:0009267] silver  
  • IEAOrtholog Compara
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IBARefGenome
Neuron fate specificationdefinition[GO:0048665] silver  
  • IBARefGenome
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IBARefGenome
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • IDAUniProtKB
Regulation of hormone levelsdefinition[GO:0010817] silver  
  • IBARefGenome
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090] silver  
  • IBARefGenome
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Tissue developmentdefinition[GO:0009888] silver  
  • IBARefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IBARefGenome
According to KEGG, this protein belongs to the following pathway:
Maturity onset diabetes of the young  hsa04950+3171  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  


Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: FOXA3
GenomeRNAi: 3171
PRO: PR:P55318