FOXA3 - Hepatocyte nuclear factor 3-gamma - human protein (Function)
 
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Gene
References

 
FOXA3 »  Hepatocyte nuclear factor 3-gamma  (HNF-3G)
 
Protein also known as:  Fork head-related protein FKH H3.
Gene name:  FOXA3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.  
2
  • UniProtKB
GO molecular function 
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • InterPro 2 GO
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134] silver  
1
  • InterPro 2 GO
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
3
  • UniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • RefGenome
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • UniProtKB
Cellular response to starvationdefinition[GO:0009267] silver  
1
  • Ortholog Compara
Chromatin modificationdefinition[GO:0016568]  
1
  • UniProtKB KW
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Maturity onset diabetes of the young  hsa04950+3171  
According to Reactome, this protein belongs to the following pathway:
Regulation of gene expression in beta cells  REACT_13819  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXA3
GenomeRNAi: 3171
PRO: PR:P55318