OXCT1 - Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial - human protein (Function)
 
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OXCT1 »  Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial   [ EC 2.8.3.5 ]
 
Protein also known as:  Somatic-type succinyl-CoA:3-oxoacid CoA-transferase (SCOT-s).
Gene name:  OXCT1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

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Overview 
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.  
1
  • UniProtKB
GO molecular function 
3-oxoacid CoA-transferase activitydefinition[GO:0008260]  
2
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cellular ketone body metabolic processdefinition[GO:0046950]  
1
  • UniProtKB
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Ketone catabolic processdefinition[GO:0042182] silver  
1
  • Ortholog Compara
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774] silver  
1
  • Ortholog Compara
Response to activitydefinition[GO:0014823] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to hormonedefinition[GO:0009725] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to starvationdefinition[GO:0042594] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.3.5: Succinyl-CoA + a 3-oxo acid succinate + a 3-oxoacyl-CoA.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+5019  
Synthesis and degradation of ketone bodies  hsa00072+5019  
Valine, leucine and isoleucine degradation  hsa00280+5019  
According to Reactome, this protein belongs to the following pathway:
Utilization of Ketone Bodies  REACT_59  
 
More information is available from:
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OXCT1
GenomeRNAi: 5019
PRO: PR:P55809