EIF3B - Eukaryotic translation initiation factor 3 subunit B - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
EIF3B »  Eukaryotic translation initiation factor 3 subunit B  (eIF3b)
 
Protein also known as:  Eukaryotic translation initiation factor 3 subunit 9.
Gene name:  EIF3B
Family name: eIF-3 subunit B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 2
GENE REF ISO

Function

 show evidences
Overview 
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  
1
  • CuratedUniProtKB
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • TASUniProtKB
Contributes to translation initiation factor activitydefinition[GO:0003743]  
4
  • ICUniProtKB
Translation initiation factor bindingdefinition[GO:0031369] silver  
  • IEAInterPro 2 GO
GO biological process 
Formation of translation preinitiation complexdefinition[GO:0001731]  
  • IEAUniProtKB Annot
Regulation of translational initiationdefinition[GO:0006446]  
1
  • IDAUniProtKB
Translational initiationdefinition[GO:0006413]  
4
  • ICUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+8662  
According to Reactome, this protein belongs to the following pathways:
3' -UTR-mediated translational regulation  REACT_1762  
Gene Expression  REACT_71  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EIF3B
GenomeRNAi: 8662
PRO: PR:P55884