RAG2 - V(D)J recombination-activating protein 2 - human protein (Sequence)
 
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RAG2 »  V(D)J recombination-activating protein 2  (RAG-2)
 
Gene name:  RAG2
Family name: RAG2
Entry whose protein(s) existence is based on evidence at protein level
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1 48 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   527 aaMass: 59241 Da,  pI: 5.56
MSLQMVTVSN NIALIQPGFS LMNFDGQVFF FGQKGWPKRS CPTGVFHLDV KHNHVKLKPT IFSKDSCYLP PLRYPATCTF KGSLESEKHQ YIIHGGKTPN NEVSDKIYVM SIVCKNNKKV TFRCTEKDLV GDVPEARYGH SINVVYSRGK SMGVLFGGRS YMPSTHRTTE KWNSVADCLP CVFLVDFEFG CATSYILPEL QDGLSFHVSI AKNDTIYILG GHSLANNIRP ANLYRIRVDL PLGSPAVNCT VLPGGISVSS AILTQTNNDE FVIVGGYQLE NQKRMICNII SLEDNKIEIR EMETPDWTPD IKHSKIWFGS NMGNGTVFLG IPGDNKQVVS EGFYFYMLKC AEDDTNEEQT TFTNSQTSTE DPGDSTPFED SEEFCFSAEA NSFDGDDEFD TYNEDDEEDE SETGYWITCC PTCDVDINTW VPFYSTELNK PAMIYCSHGD GHWVHAQCMD LAERTLIHLS AGSNKYYCNE HVEIARALHT PQRVLPLKKP PMKSLRKKGS GKILTPAKKS FLRRLFD

Sequence

 show evidences
Domain 
The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). The presence Tyr-445 instead of a carboxylate in classical PHD-type zinc fingers results in an enhanced binding to H3K4me3 in presence of dimethylated on 'Arg-2' (H3R2me2) rather than inhibited. The atypical PHD-type zinc finger also binds various phosphoinositides, such as phosphatidylinositol 3,4-bisphosphate binding (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate binding (PtdIns(3,5)P2), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate binding (PtdIns(3,4,5)P3) (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Zinc-finger  definition   [KW-0863]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.120.10.80
InterPro: IPR025162 [ RAG2 PHD ]
InterPro: IPR004321 [ RAG2 ]
InterPro: IPR011043 [ Gal Oxase/kelch b-propeller ]
InterPro: IPR015915 [ Kelch-typ b-propeller ]
InterPro: IPR011011 [ Znf FYVE PHD ]
PANTHER: PTHR10960 [ PTHR10960 ]
Pfam: PF03089 [ RAG2 ]
Pfam: PF13341 [ RAG2 PHD ]
SUPFAM: SSF50965 [ SSF50965 ]
SUPFAM: SSF57903 [ SSF57903 ]
Genome annotation databases
Ensembl: Transcript: ENST00000311485;  Protein: ENSP00000308620;  Gene: ENSG00000175097.
Ensembl: Transcript: ENST00000529083;  Protein: ENSP00000436327;  Gene: ENSG00000175097.
Ensembl: Transcript: ENST00000527033;  Protein: ENSP00000436895;  Gene: ENSG00000175097.
Ensembl: Transcript: ENST00000532616;  Protein: ENSP00000432174;  Gene: ENSG00000175097.
KEGG: hsa:5897
UCSC: uc001mwv.4
Organism-specific databases
MGI: MGI:97849 [ Rag2 ]
PTM databases
PhosphoSite: P55895
Phylogenomic databases
eggNOG: NOG39310
HOGENOM: HOG000237346
HOVERGEN: HBG006694
InParanoid: P55895
KO: K10988
OMA: FGQKGWP
OrthoDB: EOG73804B
PhylomeDB: P55895
Sequence databases
CCDS: CCDS7903.1 [ P55895-1 ]
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68117.1 .
EMBL: mRNA:  AK292664 . Translation:  BAF85353.1 .
EMBL: mRNA:  BC022397 . Translation:  AAH22397.1 .
EMBL: Genomic DNA:  M94633 . No translation available.
IPI: IPI00299162
RefSeq: Protein:  NP_001230715.1. Nucleotide sequence:  NM_001243786.1.
RefSeq: Protein:  NP_000527.2. Nucleotide sequence:  NM_000536.3.
RefSeq: Protein:  NP_001230714.1. Nucleotide sequence:  NM_001243785.1.
UniProtKB: P55895
Protocols and materials databases
DNASU: 5897