DLX5 - Homeobox protein DLX-5 - human protein (Function)
 
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DLX5 »  Homeobox protein DLX-5
 
Gene name:  DLX5
Family name: Distal-less homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.  
1
  • CuratedUniProtKB
GO molecular function 
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
  • ISSOrtholog Curator
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Anatomical structure formation involved in morphogenesisdefinition[GO:0048646] silver  
  • IEAOrtholog Compara
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
BMP signaling pathwaydefinition[GO:0030509]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
Cellular response to BMP stimulusdefinition[GO:0071773]  
  • ISSOrtholog Curator
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IEAOrtholog Compara
Endochondral ossificationdefinition[GO:0001958]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855] silver  
  • IEAOrtholog Compara
Face morphogenesisdefinition[GO:0060325] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Olfactory pit developmentdefinition[GO:0060166] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
  • ISSOrtholog Curator
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusdefinition[GO:1901522]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
 

Keywords

Biological process 
Osteogenesis  definition   [KW-0892]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DLX5
GenomeRNAi: 1749
PRO: PR:P56178