AP1S2 - AP-1 complex subunit sigma-2 - human protein (Function)
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AP1S2 »  AP-1 complex subunit sigma-2
Protein also known as:  Clathrin assembly protein complex 1 sigma-1B small chain.
Gene name:  AP1S2
Entry whose protein(s) existence is based on evidence at protein level
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Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  
  • CuratedUniProtKB
GO molecular function 
Protein transporter activitydefinition[GO:0008565] silver  
  • IEAInterPro 2 GO
GO biological process 
Intracellular protein transportdefinition[GO:0006886] silver  
  • IEAInterPro 2 GO
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+8905  
According to Reactome, this protein belongs to the following pathways:
Golgi Associated Vesicle Biogenesis  REACT_19400  
Lysosome Vesicle Biogenesis  REACT_19287  
MHC class II antigen presentation  REACT_121399  
Nef mediated downregulation of MHC class I complex cell surface expression  REACT_11103  


Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: AP1S2
GenomeRNAi: 8905
PRO: PR:P56377