CAV3 - Caveolin-3 - human protein (Function)
 
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CAV3 »  Caveolin-3
 
Protein also known as:  M-caveolin.
Gene name:  CAV3
Family name: Caveolin
Entry whose protein(s) existence is based on evidence at protein level
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1 87 1
GENE REF ISO

Function

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Overview 
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.  
  • CuratedUniProtKB
GO molecular function 
Alpha-tubulin bindingdefinition[GO:0043014] silver  
  • IEAOrtholog Compara
Calcium channel regulator activitydefinition[GO:0005246]  
1
  • IDABHF-UCL
Connexin bindingdefinition[GO:0071253]  
1
  • IDABHF-UCL
Ion channel bindingdefinition[GO:0044325]  
2
  • IPIBHF-UCL
Nitric-oxide synthase bindingdefinition[GO:0050998] silver  
  • IEAOrtholog Compara
Potassium channel inhibitor activitydefinition[GO:0019870]  
1
  • ISSBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IDAUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAUniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • IPIBHF-UCL
  • ISSOrtholog Curator
Sodium channel regulator activitydefinition[GO:0017080]  
2
  • IMPBHF-UCL
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
  • IEAOrtholog Compara
Cardiac muscle cell developmentdefinition[GO:0055013] silver  
  • IEAOrtholog Compara
Caveola assemblydefinition[GO:0070836]  
1
  • IDAMGI
Cell differentiationdefinition[GO:0030154]  
  • ISSOrtholog Curator
Cell growthdefinition[GO:0016049]  
  • ISSOrtholog Curator
Cholesterol homeostasisdefinition[GO:0042632]  
  • ISSOrtholog Curator
Cytoplasmic microtubule organizationdefinition[GO:0031122] silver  
  • IEAOrtholog Compara
Endocytosisdefinition[GO:0006897]  
  • ISSOrtholog Curator
Establishment of protein localization to plasma membranedefinition[GO:0090002] silver  
  • IEAOrtholog Compara
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Heart trabecula formationdefinition[GO:0060347] silver  
  • IEAOrtholog Compara
Membrane raft organizationdefinition[GO:0031579]  
  • ISSOrtholog Curator
Muscle cell cellular homeostasisdefinition[GO:0046716]  
  • ISSOrtholog Curator
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASUniProtKB
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Negative regulation of calcium ion transportdefinition[GO:0051926]  
1
  • IDAMGI
Negative regulation of cardiac muscle hypertrophydefinition[GO:0010614]  
1
  • IMPBHF-UCL
Negative regulation of cell growth involved in cardiac muscle cell developmentdefinition[GO:0061052] silver  
  • IEAOrtholog Compara
Negative regulation of cell sizedefinition[GO:0045792]  
1
  • IMPBHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IMPBHF-UCL
Negative regulation of MAPK cascadedefinition[GO:0043409]  
  • ISSOrtholog Curator
Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001]  
  • ISSOrtholog Curator
Negative regulation of potassium ion transmembrane transportdefinition[GO:1901380]  
1
  • ISSBHF-UCL
Negative regulation of potassium ion transmembrane transporter activitydefinition[GO:1901017]  
1
  • ISSBHF-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
  • ISSOrtholog Curator
Negative regulation of protein localization to cell surfacedefinition[GO:2000009]  
1
  • NASBHF-UCL
Negative regulation of sarcomere organizationdefinition[GO:0060299]  
1
  • IMPBHF-UCL
Nucleus localizationdefinition[GO:0051647] silver  
  • IEAOrtholog Compara
Plasma membrane organizationdefinition[GO:0007009]  
  • ISSOrtholog Curator
Plasma membrane repairdefinition[GO:0001778] silver  
  • IEAOrtholog Compara
Positive regulation of caveolin-mediated endocytosisdefinition[GO:2001288] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
  • ISSOrtholog Curator
Positive regulation of microtubule polymerizationdefinition[GO:0031116]  
  • ISSOrtholog Curator
Positive regulation of myotube differentiationdefinition[GO:0010831] silver  
  • IEAOrtholog Compara
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • NASBHF-UCL
Protein localizationdefinition[GO:0008104]  
  • ISSOrtholog Curator
Protein localization to plasma membranedefinition[GO:0072659]  
  • ISSOrtholog Curator
Regulation of branching involved in mammary gland duct morphogenesisdefinition[GO:0060762] silver  
  • IEAOrtholog Compara
Regulation of calcium ion importdefinition[GO:0090279]  
1
  • IDABHF-UCL
Regulation of calcium ion transmembrane transporter activitydefinition[GO:1901019]  
1
  • IDABHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • IMPBHF-UCL
Regulation of heart contractiondefinition[GO:0008016]  
  • ISSOrtholog Curator
Regulation of heart ratedefinition[GO:0002027]  
1
  • IMPBHF-UCL
Regulation of membrane depolarization during cardiac muscle cell action potentialdefinition[GO:1900825]  
1
  • IMPBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Regulation of nerve growth factor receptor activitydefinition[GO:0051394]  
1
  • IMPMGI
Regulation of p38MAPK cascadedefinition[GO:1900744] silver  
  • IEAOrtholog Compara
Regulation of protein kinase B signalingdefinition[GO:0051896] silver  
  • IEAOrtholog Compara
Regulation of signal transduction by receptor internalizationdefinition[GO:0038009]  
1
  • IMPMGI
Regulation of skeletal muscle contractiondefinition[GO:0014819]  
1
  • IMPBHF-UCL
Regulation of sodium ion transmembrane transporter activitydefinition[GO:2000649]  
2
  • IDABHF-UCL
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015] silver  
  • IEAOrtholog Compara
Regulation of ventricular cardiac muscle cell membrane depolarizationdefinition[GO:0060373]  
1
  • IDABHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
T-tubule organizationdefinition[GO:0033292]  
1
  • TASBHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
  • ISSOrtholog Curator
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • ISSBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+859  
Endocytosis  hsa04144+859  
Focal adhesion  hsa04510+859  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Caveolin_3
GenomeRNAi: 859
PRO: PR:P56539