CTBP2 - C-terminal-binding protein 2 - human protein (Function)
 
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CTBP2 »  C-terminal-binding protein 2  (CtBP2)
 
Gene name:  CTBP2
Entry whose protein(s) existence is based on evidence at protein level
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1 70 2
GENE REF ISO

Function

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Overview 
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).  
1
  • UniProtKB
Isoform  Iso 2   Probably acts as a scaffold for specialized synapses.  
1
  • UniProtKB
GO molecular function 
NAD bindingdefinition[GO:0051287] silver  
1
  • InterPro 2 GO
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptordefinition[GO:0016616] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Transcription corepressor activitydefinition[GO:0003714] silver  
1
  • Ortholog Compara
GO biological process 
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • Ortholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Positive regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048386]  
1
  • MGI
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • MGI
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Viral genome replicationdefinition[GO:0019079]  
1
  • PINC
White fat cell differentiationdefinition[GO:0050872]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chronic myeloid leukemia  hsa05220+1488  
Notch signaling pathway  hsa04330+1488  
Pathways in cancer  hsa05200+1488  
Wnt signaling pathway  hsa04310+1488  
According to Reactome, this protein belongs to the following pathways:
repression of WNT target genes  REACT_228106  
TCF7L2 mutants don't bind CTBP  REACT_228223  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CTBP2
GenomeRNAi: 1488
PRO: PR:P56545