KCNQ4 - Potassium voltage-gated channel subfamily KQT member 4 - human protein (Function)
 
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References

 
KCNQ4 »  Potassium voltage-gated channel subfamily KQT member 4
 
Protein also known as:  Voltage-gated potassium channel subunit Kv7.4.
Gene name:  KCNQ4
Entry whose protein(s) existence is based on evidence at protein level
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1 44 2
GENE REF ISO

Function

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Overview 
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.15.4  
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251] silver  
  • IBARefGenome
Potassium channel activitydefinition[GO:0005267]  
1
  • TASPINC
GO biological process 
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+9132  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Hearing  definition   [KW-1009]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNQ4
GenomeRNAi: 9132
PRO: PR:P56696
Chemistry
GuidetoPHARMACOLOGY: 563