WNT7B - Protein Wnt-7b - human protein (Function)
 
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WNT7B »  Protein Wnt-7b
 
Gene name:  WNT7B
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).  
1
  • UniProtKB
GO molecular function 
Frizzled bindingdefinition[GO:0005109]  
1
  • RefGenome
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257] silver  
1
  • Ortholog Compara
Anatomical structure regressiondefinition[GO:0060033] silver  
1
  • Ortholog Compara
Apoptotic process involved in patterning of blood vesselsdefinition[GO:1902262] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • Ortholog Curator
Cell fate commitmentdefinition[GO:0045165]  
1
  • RefGenome
Cellular metabolic processdefinition[GO:0044237]  
1
  • Ortholog Curator
Cellular response to retinoic aciddefinition[GO:0071300]  
2
  • UniProtKB
Central nervous system vasculogenesisdefinition[GO:0022009]  
1
  • Ortholog Curator
Chorio-allantoic fusiondefinition[GO:0060710]  
1
  • Ortholog Curator
Developmental growth involved in morphogenesisdefinition[GO:0060560]  
1
  • Ortholog Curator
Embryonic organ developmentdefinition[GO:0048568]  
1
  • Ortholog Curator
Embryonic placenta morphogenesisdefinition[GO:0060669]  
1
  • Ortholog Curator
Establishment or maintenance of polarity of embryonic epitheliumdefinition[GO:0016332]  
1
  • Ortholog Curator
Fibroblast proliferationdefinition[GO:0048144]  
1
  • UniProtKB
Forebrain regionalizationdefinition[GO:0021871]  
1
  • UniProtKB
Homeostatic processdefinition[GO:0042592]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
1
  • Ortholog Curator
Inner medullary collecting duct developmentdefinition[GO:0072061]  
1
  • Ortholog Curator
Lens fiber cell developmentdefinition[GO:0070307]  
1
  • BHF-UCL
Lobar bronchus developmentdefinition[GO:0060482]  
1
  • Ortholog Curator
Lung developmentdefinition[GO:0030324]  
1
  • Ortholog Curator
Lung epithelium developmentdefinition[GO:0060428]  
1
  • Ortholog Curator
Lung morphogenesisdefinition[GO:0060425]  
1
  • Ortholog Curator
Lung-associated mesenchyme developmentdefinition[GO:0060484] silver  
1
  • Ortholog Compara
Mammary gland epithelium developmentdefinition[GO:0061180]  
1
  • UniProtKB
Metanephric collecting duct developmentdefinition[GO:0072205]  
1
  • Ortholog Curator
Metanephric epithelium developmentdefinition[GO:0072207]  
1
  • Ortholog Curator
Metanephric loop of Henle developmentdefinition[GO:0072236]  
1
  • Ortholog Curator
Metanephros morphogenesisdefinition[GO:0003338]  
1
  • Ortholog Curator
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182]  
1
  • UniProtKB
Neuron projection morphogenesisdefinition[GO:0048812] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Outer medullary collecting duct developmentdefinition[GO:0072060]  
1
  • Ortholog Curator
Oxygen homeostasisdefinition[GO:0032364]  
1
  • Ortholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • RefGenome
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • Ortholog Curator
Regulation of cell projection sizedefinition[GO:0032536] silver  
1
  • Ortholog Compara
Renal inner medulla developmentdefinition[GO:0072053]  
1
  • Ortholog Curator
Renal outer medulla developmentdefinition[GO:0072054]  
1
  • Ortholog Curator
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
1
  • Ortholog Compara
Stem cell proliferationdefinition[GO:0072089]  
1
  • UniProtKB
Synapse organizationdefinition[GO:0050808]  
1
  • Ortholog Curator
Trachea cartilage morphogenesisdefinition[GO:0060535]  
1
  • Ortholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
2
  • RefGenome
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7477  
Hedgehog signaling pathway  hsa04340+7477  
HTLV-I infection  hsa05166+7477  
Melanogenesis  hsa04916+7477  
Pathways in cancer  hsa05200+7477  
Wnt signaling pathway  hsa04310+7477  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
WNT ligand biogenesis and trafficking  REACT_163710  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT7B
GenomeRNAi: 7477
PRO: PR:P56706