CLDN15 - Claudin-15 - human protein (Function)
 
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Protein
Gene
References

 
CLDN15 »  Claudin-15
 
Gene name:  CLDN15
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the claudin tight junction (claudin) family  1.H.1.1.9  
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338]  
  • ISSOrtholog Curator
Ion transportdefinition[GO:0006811]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+24146  
Hepatitis C  hsa05160+24146  
Leukocyte transendothelial migration  hsa04670+24146  
Tight junction  hsa04530+24146  
According to Reactome, this protein belongs to the following pathway:
Tight junction interactions  REACT_19373  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN15
GenomeRNAi: 24146
PRO: PR:P56746