BACE1 - Beta-secretase 1 - human protein (Function)
 
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BACE1 »  Beta-secretase 1   [ EC 3.4.23.46 ]
 
Protein also known as:  Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1).
Gene name:  BACE1
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the -amyloid cleaving enzyme (bace1) family  8.A.32.1.1  
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
1
  • IDAUniProtKB
Beta-aspartyl-peptidase activitydefinition[GO:0008798]  
1
  • TASPINC
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
GO biological process 
Beta-amyloid metabolic processdefinition[GO:0050435]  
1
  • IDAUniProtKB
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • TASUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.46: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer amyloid precursor protein.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by RTN3 and RTN4.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Alzheimer's disease  hsa05010+23621  
 
More information is available from:
 

Keywords

Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P56817
Other
GeneWiki: Beta-secretase_1
GenomeRNAi: 23621
PRO: PR:P56817
Chemistry
GuidetoPHARMACOLOGY: 2330