GSC - Homeobox protein goosecoid - human protein (Function)
 
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GSC »  Homeobox protein goosecoid
 
Gene name:  GSC
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
  • IEAOrtholog Compara
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
  • IEAOrtholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Gastrulationdefinition[GO:0007369]  
1
  • NASUniProtKB
Middle ear morphogenesisdefinition[GO:0042474]  
  • ISSOrtholog Curator
Muscle organ morphogenesisdefinition[GO:0048644] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GSC_(gene)
GenomeRNAi: 145258
PRO: PR:P56915