GSC - Homeobox protein goosecoid - human protein (Function)
 
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GSC »  Homeobox protein goosecoid
 
Gene name:  GSC
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
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1 15 1
GENE REF ISO

Function

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Overview 
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.  
2
  • UniProtKB
GO molecular function 
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • Ortholog Curator
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • Ortholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
GO biological process 
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
1
  • Ortholog Compara
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
1
  • Ortholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Gastrulationdefinition[GO:0007369]  
1
  • UniProtKB
Middle ear morphogenesisdefinition[GO:0042474]  
1
  • Ortholog Curator
Muscle organ morphogenesisdefinition[GO:0048644] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178] silver  
1
  • Ortholog Compara
Neural crest cell fate specificationdefinition[GO:0014036]  
1
  • UniProtKB
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
1
  • Ortholog Compara
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GSC_(gene)
GenomeRNAi: 145258
PRO: PR:P56915