HSD17B7 - 3-keto-steroid reductase - human protein (Function)
 
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Protein
Gene
References

 
HSD17B7 »  3-keto-steroid reductase   [ EC 1.1.1.270 ]
 
Protein also known as:  17-beta-hydroxysteroid dehydrogenase 7 (17-beta-HSD 7).
Gene name:  HSD17B7
Entry whose protein(s) existence is based on evidence at protein level
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1 29 3
GENE REF ISO

Function

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Overview 
Responsible for the reduction of the keto group on the C-3 of sterols.  
1
  • CuratedUniProtKB
GO molecular function 
3-keto sterol reductase activitydefinition[GO:0000253]  
  • IEAEC 2 GO
Estradiol 17-beta-dehydrogenase activitydefinition[GO:0004303]  
  • IEAEC 2 GO
Prolactin receptor bindingdefinition[GO:0005148] silver  
  • IEAOrtholog Compara
GO biological process 
Estrogen biosynthetic processdefinition[GO:0006703]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.270: A 3-beta-hydroxysteroid + NADP(+) a 3-oxosteroid + NADPH.  
  • CuratedUniProtKB
EC 1.1.1.62: 17-beta-estradiol + NAD(P)(+) estrone + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+51478  
Steroid biosynthesis  hsa00100+51478  
Steroid hormone biosynthesis  hsa00140+51478  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P56937
Other
GeneWiki: HSD17B7
GenomeRNAi: 51478
PRO: PR:P56937