BCAR1 - Breast cancer anti-estrogen resistance protein 1 - human protein (Function)
 
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Protein
Gene
References

 
BCAR1 »  Breast cancer anti-estrogen resistance protein 1
 
Protein also known as:  Cas scaffolding protein family member 1.
Gene name:  BCAR1
Family name: CAS
Entry whose protein(s) existence is based on evidence at protein level
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1 212 8
GENE REF ISO

Function

 show evidences
Overview 
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
23
  • IPIUniProtKB
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
5
  • IPIUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin filament organizationdefinition[GO:0007015]  
1
  • IDAUniProtKB
Antigen receptor-mediated signaling pathwaydefinition[GO:0050851]  
1
  • IDAUniProtKB
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • IDAUniProtKB
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell chemotaxisdefinition[GO:0060326]  
1
  • IMPBHF-UCL
Cell divisiondefinition[GO:0051301]  
1
  • NASUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IDAUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cellular response to hepatocyte growth factor stimulusdefinition[GO:0035729]  
1
  • IMPBHF-UCL
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
  • ISSOrtholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Hepatocyte growth factor receptor signaling pathwaydefinition[GO:0048012]  
1
  • IMPBHF-UCL
Insulin receptor signaling pathwaydefinition[GO:0008286]  
  • ISSOrtholog Curator
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • IDAUniProtKB
Neurotrophin TRK receptor signaling pathwaydefinition[GO:0048011]  
  • ISSOrtholog Curator
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDABHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of cell growthdefinition[GO:0001558]  
1
  • TASUniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • NASUniProtKB
Vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0048010]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+9564  
Chemokine signaling pathway  hsa04062+9564  
Focal adhesion  hsa04510+9564  
Leukocyte transendothelial migration  hsa04670+9564  
Regulation of actin cytoskeleton  hsa04810+9564  
According to Reactome, this protein belongs to the following pathways:
Downstream signal transduction  REACT_17025  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCAR1
GenomeRNAi: 9564
PRO: PR:P56945