TMPRSS3 - Transmembrane protease serine 3 - human protein (Function)
 
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TMPRSS3 »  Transmembrane protease serine 3   [ EC 3.4.21.- ]
 
Protein also known as:  Tumor-associated differentially-expressed gene 12 protein.
Gene name:  TMPRSS3
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).  
1
  • CuratedUniProtKB
GO molecular function 
Scavenger receptor activitydefinition[GO:0005044] silver  
  • IEAInterPro 2 GO
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • NASUniProtKB
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • IDAMGI
GO biological process 
Cellular sodium ion homeostasisdefinition[GO:0006883]  
1
  • IDAMGI
Proteolysisdefinition[GO:0006508]  
1
  • NASUniProtKB
Receptor-mediated endocytosisdefinition[GO:0006898]  
  • IEAInterPro 2 GO
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TMPRSS3
GenomeRNAi: 64699
PRO: PR:P57727