TMPRSS3 - Transmembrane protease serine 3 - human protein (Sequence)
 
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TMPRSS3 »  Transmembrane protease serine 3   [ EC 3.4.21.- ]
 
Protein also known as:  Tumor-associated differentially-expressed gene 12 protein.
Gene name:  TMPRSS3
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Displayed isoform: A     

 
 
Isoform A   454 aaMass: 49405 Da,  pI: 5.95
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT

Sequence

 show evidences
PTM 
Undergoes autoproteolytic activation.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Signal-anchor  definition   [KW-0735]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Zymogen  definition   [KW-0865]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 4.10.400.10
InterPro: IPR017448 [ Srcr rcpt-rel ]
InterPro: IPR001314 [ Peptidase S1A ]
InterPro: IPR002172 [ LDrepeatLR classA rpt ]
InterPro: IPR023415 [ LDLR class-A CS ]
InterPro: IPR018114 [ Peptidase S1 AS ]
InterPro: IPR001190 [ SRCR ]
InterPro: IPR001254 [ Peptidase S1 ]
InterPro: IPR009003 [ Trypsin-like Pept dom ]
Pfam: PF00089 [ Trypsin ]
Pfam: PF00057 [ Ldl recept a ]
PRINTS: PR00722 [ CHYMOTRYPSIN ]
PROSITE: PS50287 [ SRCR 2 ]
PROSITE: PS00135 [ TRYPSIN SER ]
PROSITE: PS50068 [ LDLRA 2 ]
PROSITE: PS01209 [ LDLRA 1 ]
PROSITE: PS00420 [ SRCR 1 ]
PROSITE: PS50240 [ TRYPSIN DOM ]
PROSITE: PS00134 [ TRYPSIN HIS ]
SMART: SM00202 [ SR ]
SMART: SM00020 [ Tryp SPc ]
SMART: SM00192 [ LDLa ]
SUPFAM: SSF56487 [ SSF56487 ]
SUPFAM: SSF50494 [ SSF50494 ]
SUPFAM: SSF57424 [ SSF57424 ]
Genome annotation databases
Ensembl: Transcript: ENST00000291532;  Protein: ENSP00000291532;  Gene: ENSG00000160183.
Ensembl: Transcript: ENST00000398397;  Protein: ENSP00000381434;  Gene: ENSG00000160183.
Ensembl: Transcript: ENST00000380399;  Protein: ENSP00000369762;  Gene: ENSG00000160183.
Ensembl: Transcript: ENST00000398405;  Protein: ENSP00000381442;  Gene: ENSG00000160183.
Ensembl: Transcript: ENST00000433957;  Protein: ENSP00000411013;  Gene: ENSG00000160183.
KEGG: hsa:64699
UCSC: uc002zaz.3
Organism-specific databases
MGI: MGI:2155445 [ Tmprss3 ]
PTM databases
PhosphoSite: P57727
Phylogenomic databases
eggNOG: COG5640
HOGENOM: HOG000251822
HOVERGEN: HBG013304
InParanoid: P57727
KO: K09634
OMA: ITPLWIV
PhylomeDB: P57727
Sequence databases
CCDS: CCDS58790.1 [ P57727-5 ]
CCDS: CCDS13686.1 [ P57727-1 ]
CCDS: CCDS42939.1 [ P57727-3 ]
EMBL: mRNA:  AB038157 . Translation:  BAB20077.1 .
EMBL: mRNA:  AF201380 . Translation:  AAG37012.1 .
EMBL: Genomic DNA:  CH471079 . Translation:  EAX09564.1 .
EMBL: mRNA:  AY358458 . Translation:  AAQ88823.1 .
EMBL: mRNA:  AY633572 . Translation:  AAT66641.1 .
EMBL: mRNA:  AB038159 . Translation:  BAB20079.1 .
EMBL: mRNA:  BC074846 . Translation:  AAH74846.1 .
EMBL: mRNA:  AB038158 . Translation:  BAB20078.1 .
EMBL: Genomic DNA:  CH471079 . Translation:  EAX09566.1 .
EMBL: mRNA:  BC074847 . Translation:  AAH74847.1 .
EMBL: mRNA:  AK172842 . Translation:  BAD18806.1 .
EMBL: mRNA:  AB038160 . Translation:  BAB20080.1 .
EMBL: Genomic DNA:  AP001623 . No translation available.
IPI: IPI00743692
IPI: IPI00027977
IPI: IPI00220533
IPI: IPI00220534
IPI: IPI01010471
RefSeq: Protein:  NP_001243246.1. Nucleotide sequence:  NM_001256317.1.
RefSeq: Protein:  NP_076927.1. Nucleotide sequence:  NM_024022.2.
RefSeq: Protein:  NP_115781.1. Nucleotide sequence:  NM_032405.1.
RefSeq: Protein:  NP_115780.1. Nucleotide sequence:  NM_032404.2.
UniProtKB: P57727 [ TMPRSS3 ]