FOXL2 - Forkhead box protein L2 - human protein (Function)
 
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FOXL2 »  Forkhead box protein L2
 
Gene name:  FOXL2
Entry whose protein(s) existence is based on evidence at protein level
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1 119 1
GENE REF ISO

Function

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Overview 
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.  
4
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase regulator activity involved in apoptotic processdefinition[GO:0043028]  
1
  • IMPUniProtKB
DNA bindingdefinition[GO:0003677]  
2
  • IDAUniProtKB
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Estrogen receptor bindingdefinition[GO:0030331] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IBARefGenome
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • NASUniProtKB
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134] silver  
  • IBARefGenome
Ubiquitin conjugating enzyme bindingdefinition[GO:0031624]  
1
  • IPIUniProtKB
GO biological process 
Apoptotic DNA fragmentationdefinition[GO:0006309]  
1
  • IMPUniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • NASUniProtKB
Embryonic eye morphogenesisdefinition[GO:0048048] silver  
  • IBARefGenome
Extraocular skeletal muscle developmentdefinition[GO:0002074]  
1
  • IMPUniProtKB
Female somatic sex determinationdefinition[GO:0019101] silver  
  • IBARefGenome
Granulosa cell differentiationdefinition[GO:0060014] silver  
  • IEAOrtholog Compara
Menstruationdefinition[GO:0042703]  
2
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IBARefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of apoptotic processdefinition[GO:0043065]  
2
  • IGIMGI
  • IMPUniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043280]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IBARefGenome
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090] silver  
  • IBARefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IBARefGenome
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Forkhead_box_L2
GenomeRNAi: 668
PRO: PR:P58012