ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 - human protein (Function)
 
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ADAMTS12 »  A disintegrin and metalloproteinase with thrombospondin motifs 12   [ EC 3.4.24.- ]  (ADAM-TS12)
 
Gene name:  ADAMTS12
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 3
GENE REF ISO

Function

 show evidences
Overview 
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.  
3
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222]  
3
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell migrationdefinition[GO:0016477]  
1
  • IMPBHF-UCL
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • IMPBHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • IDABHF-UCL
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IMPBHF-UCL
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IMPBHF-UCL
Negative regulation of cellular response to hepatocyte growth factor stimulusdefinition[GO:2001113]  
1
  • IDABHF-UCL
Negative regulation of cellular response to vascular endothelial growth factor stimulusdefinition[GO:1902548]  
1
  • IDABHF-UCL
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
1
  • IDABHF-UCL
Negative regulation of hepatocyte growth factor receptor signaling pathwaydefinition[GO:1902203]  
1
  • IDABHF-UCL
Proteoglycan catabolic processdefinition[GO:0030167]  
1
  • IDABHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
2
  • IMPBHF-UCL
Regulation of endothelial tube morphogenesisdefinition[GO:1901509]  
1
  • IDABHF-UCL
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • IDABHF-UCL
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by alpha-2 macroglobulin.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
O-glycosylation of TSR domain-containing proteins  REACT_200626  
 

Biophysicochemical properties

Dependence
pH Optimum pH is between 7.5 and 9.5 with COMP for substrate.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS12
GenomeRNAi: 81792
PRO: PR:P58397