ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ADAMTS12 »  A disintegrin and metalloproteinase with thrombospondin motifs 12   [ EC 3.4.24.- ]  (ADAM-TS12)
 
Gene name:  ADAMTS12
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 3
GENE REF ISO

Function

 show evidences
Overview 
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.  
3
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by alpha-2 macroglobulin.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH Optimum pH is between 7.5 and 9.5 with COMP for substrate.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS12
GenomeRNAi: 81792
PRO: PR:P58397