ADAMTS20 - A disintegrin and metalloproteinase with thrombospondin motifs 20 - human protein (Function)
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ADAMTS20 »  A disintegrin and metalloproteinase with thrombospondin motifs 20   [ EC 3.4.24.- ]  (ADAMTS-20)
Gene name:  ADAMTS20
Entry whose protein(s) existence is based on evidence at protein level
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May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.  
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Positive regulation of melanocyte differentiationdefinition[GO:0045636] silver  
  • IEAOrtholog Compara
Positive regulation of signal transductiondefinition[GO:0009967] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
More information is available from:
According to Reactome, this protein belongs to the following pathway:
O-glycosylation of TSR domain-containing proteins  REACT_200626  


Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 80070
PRO: PR:P59510