TAS2R43 - Taste receptor type 2 member 43 - human protein (Function)
 
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Protein
Gene
References

 
TAS2R43 »  Taste receptor type 2 member 43  (T2R43)
 
Protein also known as:  Taste receptor type 2 member 52 (T2R52).
Gene name:  TAS2R43
Entry whose protein(s) existence is based on evidence at transcript level
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1 12 1
GENE REF ISO

Function

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Overview 
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Bitter taste receptor activitydefinition[GO:0033038]  
1
  • IDAHGNC
Taste receptor activitydefinition[GO:0008527]  
1
  • IDAHGNC
GO biological process 
Detection of chemical stimulus involved in sensory perception of bitter tastedefinition[GO:0001580]  
1
  • IDAHGNC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • ICHGNC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+259289  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Taste  definition   [KW-0919]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAS2R43
GenomeRNAi: 259289
PRO: PR:P59537