TAS2R46 - Taste receptor type 2 member 46 - human protein (Function)
 
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Protein
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TAS2R46 »  Taste receptor type 2 member 46  (T2R46)
 
Protein also known as:  Taste receptor type 2 member 54 (T2R54).
Gene name:  TAS2R46
Entry whose protein(s) existence is based on evidence at transcript level
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1 17 1
GENE REF ISO

Function

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Overview 
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
Sensory perception of tastedefinition[GO:0050909]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+259292  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Taste  definition   [KW-0919]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAS2R46
GenomeRNAi: 259292
PRO: PR:P59540