CD81 - CD81 antigen - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CD81 »  CD81 antigen
 
Protein also known as:  Target of the antiproliferative antibody 1; CD antigen CD81.
Gene name:  CD81
Family name: Tetraspanin (TM4SF)
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 133 1
GENE REF ISO

Function

 show evidences
Overview 
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the tetraspanin (tetraspanin) family  8.A.40.1.1  
GO molecular function 
MHC class II protein complex bindingdefinition[GO:0023026]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • UniProtKB
  • IntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
1
  • UniProtKB
Phosphatidylinositol metabolic processdefinition[GO:0046488]  
1
  • UniProtKB
Positive regulation of 1-phosphatidylinositol 4-kinase activitydefinition[GO:0043128]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • UniProtKB
Protein localizationdefinition[GO:0008104]  
1
  • UniProtKB
Receptor-mediated virion attachment to host celldefinition[GO:0046813]  
1
  • UniProtKB
Viral entry into host celldefinition[GO:0046718]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+975  
Hepatitis C  hsa05160+975  
Malaria  hsa05144+975  
According to Reactome, this protein belongs to the following pathway:
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD81
GenomeRNAi: 975
PRO: PR:P60033