PTEN - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN - human protein (Function)
 
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PTEN »  Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   [ EC 3.1.3.67EC 3.1.3.48EC 3.1.3.16 ]
 
Protein also known as:  Mutated in multiple advanced cancers 1.
Gene name:  PTEN
Entry whose protein(s) existence is based on evidence at protein level
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1 1150 1
GENE REF ISO

Function

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Overview 
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.  
9
  • CuratedUniProtKB
GO molecular function 
Anaphase-promoting complex bindingdefinition[GO:0010997]  
1
  • IPIBHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activitydefinition[GO:0051717]  
1
  • IDAUniProtKB
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
PDZ domain bindingdefinition[GO:0030165]  
2
  • IPIUniProtKB
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activitydefinition[GO:0016314]  
2
  • IDAUniProtKB
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase activitydefinition[GO:0051800]  
1
  • IDAUniProtKB
Phosphatidylinositol-3-phosphatase activitydefinition[GO:0004438]  
1
  • IDAUniProtKB
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • IDABHF-UCL
Platelet-derived growth factor receptor bindingdefinition[GO:0005161] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
1
  • IDAUniProtKB
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
1
  • IDAUniProtKB
Protein tyrosine/serine/threonine phosphatase activitydefinition[GO:0008138] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of mitotic anaphase-promoting complex activitydefinition[GO:0007092]  
1
  • IDABHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
  • ISSOrtholog Curator
Brain morphogenesisdefinition[GO:0048854]  
  • ISSOrtholog Curator
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • IDABHF-UCL
Cardiac muscle tissue developmentdefinition[GO:0048738] silver  
  • IEAOrtholog Compara
Cell migrationdefinition[GO:0016477]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
  • ISSOrtholog Curator
Central nervous system myelin maintenancedefinition[GO:0032286]  
  • ISSOrtholog Curator
Central nervous system neuron axonogenesisdefinition[GO:0021955]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
  • ISSOrtholog Curator
Dentate gyrus developmentdefinition[GO:0021542]  
  • ISSOrtholog Curator
Endothelial cell migrationdefinition[GO:0043542] silver  
  • IEAOrtholog Compara
Forebrain morphogenesisdefinition[GO:0048853]  
  • ISSOrtholog Curator
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Inositol phosphate dephosphorylationdefinition[GO:0046855]  
1
  • IDAUniProtKB
Learning or memorydefinition[GO:0007611]  
  • ISSOrtholog Curator
Locomotor rhythmdefinition[GO:0045475]  
  • ISSOrtholog Curator
Locomotory behaviordefinition[GO:0007626]  
  • ISSOrtholog Curator
Long term synaptic depressiondefinition[GO:0060292] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Male mating behaviordefinition[GO:0060179] silver  
  • IEAOrtholog Compara
Maternal behaviordefinition[GO:0042711] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Multicellular organismal response to stressdefinition[GO:0033555]  
  • ISSOrtholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of axonogenesisdefinition[GO:0050771]  
  • ISSOrtholog Curator
Negative regulation of cell agingdefinition[GO:0090344] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
2
  • IMPUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
3
  • IDABHF-UCL
  • IMPUniProtKB
Negative regulation of cell sizedefinition[GO:0045792]  
  • ISSOrtholog Curator
Negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycledefinition[GO:0031658]  
1
  • IDABHF-UCL
Negative regulation of dendritic spine morphogenesisdefinition[GO:0061002]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of excitatory postsynaptic membrane potentialdefinition[GO:0090394]  
  • ISSOrtholog Curator
Negative regulation of focal adhesion assemblydefinition[GO:0051895]  
1
  • IMPUniProtKB
Negative regulation of G1/S transition of mitotic cell cycledefinition[GO:2000134]  
1
  • IDABHF-UCL
Negative regulation of myelinationdefinition[GO:0031642] silver  
  • IEAOrtholog Compara
Negative regulation of organ growthdefinition[GO:0046621]  
  • ISSOrtholog Curator
Negative regulation of phagocytosisdefinition[GO:0050765] silver  
  • IEAOrtholog Compara
Negative regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014067]  
1
  • TASBHF-UCL
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • IMPUniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • IDABHF-UCL
Negative regulation of ribosome biogenesisdefinition[GO:0090071] silver  
  • IEAOrtholog Compara
Negative regulation of synaptic vesicle clusteringdefinition[GO:2000808]  
  • ISSOrtholog Curator
Neuron-neuron synaptic transmissiondefinition[GO:0007270]  
  • ISSOrtholog Curator
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • IDAGOC
Phosphatidylinositol dephosphorylationdefinition[GO:0046856]  
3
  • IMPBHF-UCL
  • IDAUniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
  • ISSOrtholog Curator
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463]  
  • ISSOrtholog Curator
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • IDABHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IMPBHF-UCL
Postsynaptic density assemblydefinition[GO:0097107]  
  • ISSOrtholog Curator
Prepulse inhibitiondefinition[GO:0060134]  
  • ISSOrtholog Curator
Presynaptic membrane assemblydefinition[GO:0097105]  
  • ISSOrtholog Curator
Prostate gland growthdefinition[GO:0060736] silver  
  • IEAOrtholog Compara
Protein dephosphorylationdefinition[GO:0006470]  
2
  • TASUniProtKB
Protein kinase B signalingdefinition[GO:0043491]  
  • ISSOrtholog Curator
Protein stabilizationdefinition[GO:0050821]  
1
  • IDABHF-UCL
Regulation of B cell apoptotic processdefinition[GO:0002902] silver  
  • IEAOrtholog Compara
Regulation of cellular component sizedefinition[GO:0032535]  
  • ISSOrtholog Curator
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • TASUniProtKB
Regulation of myeloid cell apoptotic processdefinition[GO:0033032] silver  
  • IEAOrtholog Compara
Regulation of neuron projection developmentdefinition[GO:0010975]  
  • ISSOrtholog Curator
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • IMPUniProtKB
Response to arsenic-containing substancedefinition[GO:0046685] silver  
  • IEAOrtholog Compara
Response to ATPdefinition[GO:0033198] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to zinc iondefinition[GO:0010043] silver  
  • IEAOrtholog Compara
Rhythmic synaptic transmissiondefinition[GO:0060024]  
  • ISSOrtholog Curator
Social behaviordefinition[GO:0035176]  
  • ISSOrtholog Curator
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
Synapse maturationdefinition[GO:0060074]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.67: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O phosphatidylinositol 4,5-bisphosphate + phosphate.  
4
  • CuratedUniProtKB
EC 3.1.3.16: [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
4
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endometrial cancer  hsa05213+5728  
Focal adhesion  hsa04510+5728  
Glioma  hsa05214+5728  
Inositol phosphate metabolism  hsa00562+5728  
Melanoma  hsa05218+5728  
p53 signaling pathway  hsa04115+5728  
Pathways in cancer  hsa05200+5728  
Phosphatidylinositol signaling system  hsa04070+5728  
Prostate cancer  hsa05215+5728  
Small cell lung cancer  hsa05222+5728  
Tight junction  hsa04530+5728  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Lipid metabolism  definition   [KW-0443]
Neurogenesis  definition   [KW-0524]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTEN_(gene)
GenomeRNAi: 5728
PRO: PR:P60484