UBE2G2 - Ubiquitin-conjugating enzyme E2 G2 - human protein (Function)
 
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UBE2G2 »  Ubiquitin-conjugating enzyme E2 G2   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin carrier protein G2.
Gene name:  UBE2G2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

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Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).  
2
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
1
  • IMPUniProtKB
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IDAUniProtKB
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • IMPUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Parkinson's disease  hsa05012+7327  
Protein processing in endoplasmic reticulum  hsa04141+7327  
Ubiquitin mediated proteolysis  hsa04120+7327  
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBE2G2
GenomeRNAi: 7327
PRO: PR:P60604