ACTB - Actin, cytoplasmic 1 - human protein (Function)
 
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ACTB »  Actin, cytoplasmic 1
 
Protein also known as:  Beta-actin. Cleaved into:  Actin, cytoplasmic 1, N-terminally processed.
Gene name:  ACTB
Family name: Actin
Entry whose protein(s) existence is based on evidence at protein level
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1 132 1
GENE REF ISO

Function

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Overview 
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Kinesin bindingdefinition[GO:0019894]  
1
  • IPIUniProtKB
Nitric-oxide synthase bindingdefinition[GO:0050998]  
1
  • IPIBHF-UCL
Contributes to nucleosomal DNA bindingdefinition[GO:0031492]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Contributes to RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDAUniProtKB
Contributes to RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDAUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASUniProtKB
Tat protein bindingdefinition[GO:0030957]  
1
  • IPIBHF-UCL
GO biological process 
ATP-dependent chromatin remodelingdefinition[GO:0043044]  
1
  • IDAUniProtKB
Cellular component movementdefinition[GO:0006928]  
2
  • TASUniProtKB
Retina homeostasisdefinition[GO:0001895]  
1
  • IEPUniProtKB
Substantia nigra developmentdefinition[GO:0021762]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+60  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+60  
Bacterial invasion of epithelial cells  hsa05100+60  
Dilated cardiomyopathy  hsa05414+60  
Focal adhesion  hsa04510+60  
Gastric acid secretion  hsa04971+60  
Hypertrophic cardiomyopathy (HCM)  hsa05410+60  
Influenza A  hsa05164+60  
Leukocyte transendothelial migration  hsa04670+60  
Pathogenic Escherichia coli infection  hsa05130+60  
Phagosome  hsa04145+60  
Regulation of actin cytoskeleton  hsa04810+60  
Salmonella infection  hsa05132+60  
Shigellosis  hsa05131+60  
Tight junction  hsa04530+60  
Vibrio cholerae infection  hsa05110+60  
Viral myocarditis  hsa05416+60  
According to Reactome, this protein belongs to the following pathways:
Adherens junctions interactions  REACT_19195  
Cell-extracellular matrix interactions  REACT_20649  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Folding of actin by CCT/TriC  REACT_17050  
Formation of annular gap junctions  REACT_11049  
Gap junction degradation  REACT_11035  
HATs acetylate histones  REACT_172610  
HATs acetylate histones  REACT_197820  
Interaction between L1 and Ankyrins  REACT_22266  
Prefoldin mediated transfer of substrate to CCT/TriC  REACT_16936  
Recycling pathway of L1  REACT_22365  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
Note 
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Beta-actin
GenomeRNAi: 60
PRO: PR:P60709