SNAP25 - Synaptosomal-associated protein 25 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SNAP25 »  Synaptosomal-associated protein 25  (SNAP-25)
 
Protein also known as:  Synaptosomal-associated 25 kDa protein.
Gene name:  SNAP25
Family name: SNAP-25
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 104 2
GENE REF ISO

Function

 show evidences
Overview 
T-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
SNAP receptor activitydefinition[GO:0005484]  
1
  • RefGenome
Syntaxin-1 bindingdefinition[GO:0017075]  
1
  • UniProtKB
GO biological process 
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Neurotransmitter uptakedefinition[GO:0001504]  
1
  • UniProtKB
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • UniProtKB
Regulation of neuron projection developmentdefinition[GO:0010975] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • UniProtKB
Synaptic vesicle dockingdefinition[GO:0016081]  
1
  • UniProtKB
Synaptic vesicle exocytosisdefinition[GO:0016079]  
1
  • ParkinsonsUK-UCL
Synaptic vesicle fusion to presynaptic membranedefinition[GO:0031629]  
1
  • RefGenome
Synaptic vesicle primingdefinition[GO:0016082]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
SNARE interactions in vesicular transport  hsa04130+6616  
Synaptic vesicle cycle  hsa04721+6616  
According to Reactome, this protein belongs to the following pathways:
Acetylcholine Neurotransmitter Release Cycle  REACT_15309  
Dopamine Neurotransmitter Release Cycle  REACT_15293  
GABA synthesis, release, reuptake and degradation  REACT_23947  
Glutamate Neurotransmitter Release Cycle  REACT_12591  
Norepinephrine Neurotransmitter Release Cycle  REACT_15418  
Regulation of insulin secretion  REACT_18325  
Serotonin Neurotransmitter Release Cycle  REACT_15425  
Toxicity of botulinum toxin type A (BoNT/A)  REACT_264537  
Toxicity of botulinum toxin type C (BoNT/C)  REACT_263969  
Toxicity of botulinum toxin type E (BoNT/E)  REACT_264227  
Note 
When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNAP25
GenomeRNAi: 6616
PRO: PR:P60880