SNAP25 - Synaptosomal-associated protein 25 - human protein (Function)
 
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SNAP25 »  Synaptosomal-associated protein 25  (SNAP-25)
 
Protein also known as:  Synaptosomal-associated 25 kDa protein.
Gene name:  SNAP25
Family name: SNAP-25
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 94 2
GENE REF ISO

Function

 show evidences
Overview 
T-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
SNARE bindingdefinition[GO:0000149] silver  
  • IEAOrtholog Compara
GO biological process 
Neurotransmitter uptakedefinition[GO:0001504]  
1
  • NASUniProtKB
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • TASUniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • NASUniProtKB
Synaptic vesicle docking involved in exocytosisdefinition[GO:0016081]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
SNARE interactions in vesicular transport  hsa04130+6616  
Synaptic vesicle cycle  hsa04721+6616  
According to Reactome, this protein belongs to the following pathways:
Acetylcholine Neurotransmitter Release Cycle  REACT_15309  
Dopamine Neurotransmitter Release Cycle  REACT_15293  
GABA synthesis, release, reuptake and degradation  REACT_23947  
Glutamate Neurotransmitter Release Cycle  REACT_12591  
Norepinephrine Neurotransmitter Release Cycle  REACT_15418  
Regulation of insulin secretion  REACT_18325  
Serotonin Neurotransmitter Release Cycle  REACT_15425  
Toxicity of botulinum toxin type A (BoNT/A)  REACT_200737  
Toxicity of botulinum toxin type C (BoNT/C)  REACT_200658  
Toxicity of botulinum toxin type E (BoNT/E)  REACT_200616  
Note 
When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNAP25
GenomeRNAi: 6616
PRO: PR:P60880