SNAP25 - Synaptosomal-associated protein 25 - human protein (Function)
 
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SNAP25 »  Synaptosomal-associated protein 25  (SNAP-25)
 
Protein also known as:  Synaptosomal-associated 25 kDa protein.
Gene name:  SNAP25
Family name: SNAP-25
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
T-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
SNARE bindingdefinition[GO:0000149] silver  
  • IEAOrtholog Compara
GO biological process 
Neurotransmitter uptakedefinition[GO:0001504]  
1
  • NASUniProtKB
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • TASUniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • NASUniProtKB
Synaptic vesicle docking involved in exocytosisdefinition[GO:0016081]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
SNARE interactions in vesicular transport  hsa04130+6616  
Synaptic vesicle cycle  hsa04721+6616  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Note 
When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNAP25
GenomeRNAi: 6616
PRO: PR:P60880