PSMA6 - Proteasome subunit alpha type-6 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PSMA6 »  Proteasome subunit alpha type-6   [ EC 3.4.25.1 ]
 
Protein also known as:  Multicatalytic endopeptidase complex iota chain.
Gene name:  PSMA6
Family name: Peptidase T1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 3
GENE REF ISO

Function

 show evidences
Overview 
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.  
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
1
  • NASUniProtKB
NF-kappaB bindingdefinition[GO:0051059]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
Purine ribonucleoside triphosphate bindingdefinition[GO:0035639]  
1
  • NASBHF-UCL
RNA bindingdefinition[GO:0003723]  
2
  • NASUniProtKB
  • IDABHF-UCL
Threonine-type endopeptidase activitydefinition[GO:0004298]  
  • IEAUniProtKB KW
GO biological process 
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IMPBHF-UCL
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.25.1: Cleavage of peptide bonds with very broad specificity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Proteasome  hsa03050+5687  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  REACT_6850  
Cell Cycle  REACT_115566  
Disease  REACT_116125  
DNA Replication  REACT_383  
Gene Expression  REACT_71  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Metabolism of RNA  REACT_21257  
Mitotic M-M/G1 phases  REACT_21300  
Proteasome mediated degradation of PAK-2p34  REACT_13505  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Threonine protease  definition   [KW-0888]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PSMA6
GenomeRNAi: 5687
PRO: PR:P60900