SRP54 - Signal recognition particle 54 kDa protein - human protein (Function)
 
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References

 
SRP54 »  Signal recognition particle 54 kDa protein  (SRP54)
 
Gene name:  SRP54
Family name: GTP-binding SRP » SRP54
Entry whose protein(s) existence is based on evidence at protein level
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1 25 2
GENE REF ISO

Function

 show evidences
Overview 
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the general secretory pathway (sec) family  3.A.5.9.1  
GO molecular function 
7S RNA bindingdefinition[GO:0008312]  
2
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144]  
1
  • IDAUniProtKB
Endoplasmic reticulum signal peptide bindingdefinition[GO:0030942]  
1
  • IDAUniProtKB
GDP bindingdefinition[GO:0019003]  
1
  • IDAUniProtKB
GTP bindingdefinition[GO:0005525]  
1
  • IDAUniProtKB
Contributes to GTPase activitydefinition[GO:0003924]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • IDAMGI
GO biological process 
GTP catabolic processdefinition[GO:0006184]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Protein targeting to ERdefinition[GO:0045047]  
1
  • IMPUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
SRP-dependent cotranslational protein targeting to membranedefinition[GO:0006614]  
1
  • ICMGI
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognitiondefinition[GO:0006617]  
  • ISSOrtholog Curator
SRP-dependent cotranslational protein targeting to membrane, translocationdefinition[GO:0006616]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein export  hsa03060+6729  
According to Reactome, this protein belongs to the following pathway:
SRP-dependent cotranslational protein targeting to membrane  REACT_115902  
 

Keywords

Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6729
PRO: PR:P61011