CXCR4 - C-X-C chemokine receptor type 4 - human protein (Function)
 
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CXCR4 »  C-X-C chemokine receptor type 4  (CXCR-4)
 
Protein also known as:  Leukocyte-derived seven transmembrane domain receptor (LESTR); CD antigen CD184.
Gene name:  CXCR4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.  
13
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
C-X-C chemokine receptor activitydefinition[GO:0016494]  
1
  • NASUniProtKB
Coreceptor activitydefinition[GO:0015026]  
1
  • TASPINC
Cytokine bindingdefinition[GO:0019955] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Myosin light chain bindingdefinition[GO:0032027]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IDAUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Ameboidal cell migrationdefinition[GO:0001667] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • IMPMGI
Cellular response to cytokine stimulusdefinition[GO:0071345]  
1
  • IDAUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • NASGOC
  • IEAInterPro 2 GO
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Germ cell migrationdefinition[GO:0008354] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Motor neuron axon guidancedefinition[GO:0008045] silver  
  • IEAOrtholog Compara
Myelin maintenancedefinition[GO:0043217]  
  • ISSOrtholog Curator
Neural precursor cell proliferationdefinition[GO:0061351] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Neutrophil activationdefinition[GO:0042119] silver  
  • IEAInterPro 2 GO
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714]  
  • ISSOrtholog Curator
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAOrtholog Compara
Regulation of chemotaxisdefinition[GO:0050920]  
1
  • IMPUniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • IEPUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+7852  
Chemokine signaling pathway  hsa04062+7852  
Cytokine-cytokine receptor interaction  hsa04060+7852  
Endocytosis  hsa04144+7852  
Intestinal immune network for IgA production  hsa04672+7852  
Leukocyte transendothelial migration  hsa04670+7852  
According to Reactome, this protein belongs to the following pathways:
Binding and entry of HIV virion  REACT_6903  
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
Note 
Plerixafor (AMD3100), an antagonist of CXCR4 activity, blocks HIV-1 entry, interaction with CXCL12 and subsequent CXCR4 signaling.  
  • CuratedUniProtKB
Caution 
Was originally (PubMed8329116 and PubMed8234909) thought to be a receptor for neuropeptide Y type 3 (NPY3R) (NPY3-R).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CXCR4
GenomeRNAi: 7852
PRO: PR:P61073
Chemistry
GuidetoPHARMACOLOGY: 71