UBE2D3 - Ubiquitin-conjugating enzyme E2 D3 - human protein (Function)
 
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UBE2D3 »  Ubiquitin-conjugating enzyme E2 D3   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin-conjugating enzyme E2-17 kDa 3.
Gene name:  UBE2D3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 54 3
GENE REF ISO

Function

 show evidences
Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (By similarity).  
14
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
5
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • IDAUniProtKB
Protein K11-linked ubiquitinationdefinition[GO:0070979]  
1
  • IDAUniProtKB
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IDAUniProtKB
Protein monoubiquitinationdefinition[GO:0006513]  
1
  • IDAUniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
2
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+7323  
Ubiquitin mediated proteolysis  hsa04120+7323  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
IKK complex recruitment mediated by RIP1  REACT_25374  
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
Negative regulators of RIG-I/MDA5 signaling  REACT_198532  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  REACT_120916  
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBE2D3
GenomeRNAi: 7323
PRO: PR:P61077