UBE2K - Ubiquitin-conjugating enzyme E2 K - human protein (Function)
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UBE2K »  Ubiquitin-conjugating enzyme E2 K   [ EC ]
Protein also known as:  Ubiquitin-conjugating enzyme E2-25 kDa (Ubiquitin-conjugating enzyme E2-25K).
Gene name:  UBE2K
Entry whose protein(s) existence is based on evidence at protein level
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Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.  
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
  • IDAUniProtKB
Ubiquitin-ubiquitin ligase activitydefinition[GO:0034450]  
  • IDAUniProtKB
GO biological process 
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
  • IEAOrtholog Compara
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
  • IDAUniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032434] silver  
  • IEAOrtholog Compara
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+3093  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
Negative regulators of RIG-I/MDA5 signaling  REACT_198532  


Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: HIP2
GenomeRNAi: 3093
PRO: PR:P61086