ACTR3 - Actin-related protein 3 - human protein (Function)
 
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ACTR3 »  Actin-related protein 3
 
Protein also known as:  Actin-like protein 3.
Gene name:  ACTR3
Family name: Actin » ARP3
Entry whose protein(s) existence is based on evidence at protein level
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1 65 1
GENE REF ISO

Function

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Overview 
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.  
3
  • UniProtKB
GO molecular function 
Contributes to actin filament bindingdefinition[GO:0051015]  
1
  • FlyBase
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • FlyBase
GO biological process 
Arp2/3 complex-mediated actin nucleationdefinition[GO:0034314]  
1
  • FlyBase
Asymmetric cell divisiondefinition[GO:0008356] silver  
1
  • Ortholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • UniProtKB
Cilium morphogenesisdefinition[GO:0060271]  
1
  • UniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163] silver  
1
  • Ortholog Compara
Meiotic chromosome movement towards spindle poledefinition[GO:0016344] silver  
1
  • Ortholog Compara
Meiotic cytokinesisdefinition[GO:0033206] silver  
1
  • Ortholog Compara
Positive regulation of dendrite morphogenesisdefinition[GO:0050775] silver  
1
  • Ortholog Compara
Positive regulation of filopodium assemblydefinition[GO:0051491] silver  
1
  • Ortholog Compara
Positive regulation of lamellipodium assemblydefinition[GO:0010592] silver  
1
  • Ortholog Compara
Regulation of myosin II filament organizationdefinition[GO:0043519] silver  
1
  • Ortholog Compara
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
1
  • Ortholog Compara
Spindle localizationdefinition[GO:0051653] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
EPHB-mediated forward signaling  REACT_228085  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACTR3
GenomeRNAi: 10096
PRO: PR:P61158