ACTR3 - Actin-related protein 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ACTR3 »  Actin-related protein 3
 
Protein also known as:  Actin-like protein 3.
Gene name:  ACTR3
Family name: Actin » ARP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 1
GENE REF ISO

Function

 show evidences
Overview 
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Asymmetric cell divisiondefinition[GO:0008356] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASUniProtKB
Cilium morphogenesisdefinition[GO:0060271]  
1
  • IMPUniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163] silver  
  • IEAOrtholog Compara
Meiotic cytokinesisdefinition[GO:0033206] silver  
  • IEAOrtholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
  • IEAOrtholog Compara
Positive regulation of dendrite morphogenesisdefinition[GO:0050775] silver  
  • IEAOrtholog Compara
Positive regulation of filopodium assemblydefinition[GO:0051491] silver  
  • IEAOrtholog Compara
Positive regulation of lamellipodium assemblydefinition[GO:0010592] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Regulation of myosin II filament organizationdefinition[GO:0043519] silver  
  • IEAOrtholog Compara
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
  • IEAOrtholog Compara
Spindle localizationdefinition[GO:0051653] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACTR3
GenomeRNAi: 10096
PRO: PR:P61158