ABCE1 - ATP-binding cassette sub-family E member 1 - human protein (Function)
 
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ABCE1 »  ATP-binding cassette sub-family E member 1
 
Protein also known as:  2'-5'-oligoadenylate-binding protein.
Gene name:  ABCE1
Family name: ABC transporter » ABCE
Entry whose protein(s) existence is based on evidence at protein level
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1 42 1
GENE REF ISO

Function

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Overview 
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887] silver  
  • IEAInterPro 2 GO
Iron-sulfur cluster bindingdefinition[GO:0051536] silver  
  • IEAInterPro 2 GO
Ribonuclease inhibitor activitydefinition[GO:0008428]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • TASGOC
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
RNA catabolic processdefinition[GO:0006401]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Note 
The ABC transporter domains seem not to be functional.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6059
PRO: PR:P61221