MAX - Protein max - human protein (Function)
 
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MAX »  Protein max
 
Protein also known as:  Class D basic helix-loop-helix protein 4 (bHLHd4).
Gene name:  MAX
Family name: MAX
Entry whose protein(s) existence is based on evidence at protein level
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1 52 6
GENE REF ISO

Function

 show evidences
Overview 
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription cofactor activitydefinition[GO:0003712]  
1
  • TASPINC
GO biological process 
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
  • IEAOrtholog Compara
Cellular response to starvationdefinition[GO:0009267] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
  • IEAOrtholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Protein complex assemblydefinition[GO:0006461] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
  • IEAOrtholog Compara
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+4149  
Pathways in cancer  hsa05200+4149  
Small cell lung cancer  hsa05222+4149  
According to Reactome, this protein belongs to the following pathway:
Cyclin A:Cdk2-associated events at S phase entry  REACT_9029  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAX_(gene)
GenomeRNAi: 4149
PRO: PR:P61244