MAX - Protein max - human protein (Function)
 
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Gene
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MAX »  Protein max
 
Protein also known as:  Class D basic helix-loop-helix protein 4 (bHLHd4).
Gene name:  MAX
Family name: MAX
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
18
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
1
  • PINC
Transcription cofactor activitydefinition[GO:0003712]  
1
  • PINC
Transcription factor activity, RNA polymerase II core promoter sequence-specificdefinition[GO:0000983] silver  
1
  • Ortholog Compara
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
GO biological process 
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+4149  
Pathways in cancer  hsa05200+4149  
Small cell lung cancer  hsa05222+4149  
According to Reactome, this protein belongs to the following pathways:
Cyclin A:Cdk2-associated events at S phase entry  R-HSA-69656  
Cyclin E associated events during G1/S transition  R-HSA-69202  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAX_(gene)
GenomeRNAi: 4149
PRO: PR:P61244