HAND2 - Heart- and neural crest derivatives-expressed protein 2 - human protein (Function)
 
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HAND2 »  Heart- and neural crest derivatives-expressed protein 2
 
Protein also known as:  Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND).
Gene name:  HAND2
Entry whose protein(s) existence is based on evidence at protein level
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1 26 1
GENE REF ISO

Function

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Overview 
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
  • ISSOrtholog Curator
AT DNA bindingdefinition[GO:0003680]  
1
  • IDAUniProtKB
Contributes to E-box bindingdefinition[GO:0070888]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDAUniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134]  
  • ISSOrtholog Curator
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
GO biological process 
Adult heart developmentdefinition[GO:0007512]  
1
  • IEPBHF-UCL
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Apoptotic processdefinition[GO:0006915]  
  • ISSOrtholog Curator
Apoptotic process involved in heart morphogenesisdefinition[GO:0003278] silver  
  • IEAOrtholog Compara
Cardiac neural crest cell development involved in outflow tract morphogenesisdefinition[GO:0061309]  
  • ISSOrtholog Curator
Cardiac neural crest cell migration involved in outflow tract morphogenesisdefinition[GO:0003253] silver  
  • IEAOrtholog Compara
Cardiac right ventricle formationdefinition[GO:0003219] silver  
  • IEAOrtholog Compara
Cartilage morphogenesisdefinition[GO:0060536] silver  
  • IEAOrtholog Compara
Cell proliferation involved in outflow tract morphogenesisdefinition[GO:0061325] silver  
  • IEAOrtholog Compara
Coronary artery morphogenesisdefinition[GO:0060982] silver  
  • IEAOrtholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • NASUniProtKB
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Mesenchymal cell proliferationdefinition[GO:0010463] silver  
  • IEAOrtholog Compara
Negative regulation of cardiac muscle cell apoptotic processdefinition[GO:0010667]  
  • ISSOrtholog Curator
Negative regulation of DNA bindingdefinition[GO:0043392] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433] silver  
  • IEAOrtholog Compara
Neural crest cell developmentdefinition[GO:0014032]  
  • ISSOrtholog Curator
Noradrenergic neuron differentiationdefinition[GO:0003357]  
1
  • NASBHF-UCL
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Peripheral nervous system neuron developmentdefinition[GO:0048935] silver  
  • IEAOrtholog Compara
Positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesisdefinition[GO:2000764]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic processdefinition[GO:2000763]  
  • ISSOrtholog Curator
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of secondary heart field cardioblast proliferationdefinition[GO:0003266]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Suckling behaviordefinition[GO:0001967] silver  
  • IEAOrtholog Compara
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538]  
  • ISSOrtholog Curator
Tongue developmentdefinition[GO:0043586] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Visceral serous pericardium developmentdefinition[GO:0061032] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAND2
GenomeRNAi: 9464
PRO: PR:P61296