HAND2 - Heart- and neural crest derivatives-expressed protein 2 - human protein (Function)
 
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HAND2 »  Heart- and neural crest derivatives-expressed protein 2
 
Protein also known as:  Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND).
Gene name:  HAND2
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2
GENE REF ISO

Function

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Overview 
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).  
1
  • UniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • Ortholog Curator
AT DNA bindingdefinition[GO:0003680]  
1
  • UniProtKB
Contributes to E-box bindingdefinition[GO:0070888]  
2
  • UniProtKB
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • Ortholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • BHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • Ortholog Curator
Transcription factor bindingdefinition[GO:0008134]  
1
  • Ortholog Curator
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • Ortholog Curator
GO biological process 
Adult heart developmentdefinition[GO:0007512]  
1
  • BHF-UCL
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Apoptotic processdefinition[GO:0006915]  
1
  • Ortholog Curator
Apoptotic process involved in heart morphogenesisdefinition[GO:0003278] silver  
1
  • Ortholog Compara
Cardiac neural crest cell development involved in outflow tract morphogenesisdefinition[GO:0061309]  
1
  • Ortholog Curator
Cardiac neural crest cell migration involved in outflow tract morphogenesisdefinition[GO:0003253] silver  
1
  • Ortholog Compara
Cardiac right ventricle formationdefinition[GO:0003219] silver  
1
  • Ortholog Compara
Cartilage morphogenesisdefinition[GO:0060536] silver  
1
  • Ortholog Compara
Cell proliferation involved in outflow tract morphogenesisdefinition[GO:0061325] silver  
1
  • Ortholog Compara
Coronary artery morphogenesisdefinition[GO:0060982] silver  
1
  • Ortholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • UniProtKB
Heart loopingdefinition[GO:0001947]  
1
  • Ortholog Curator
Heart morphogenesisdefinition[GO:0003007]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
1
  • Ortholog Curator
Mesenchymal cell proliferationdefinition[GO:0010463] silver  
1
  • Ortholog Compara
Negative regulation of cardiac muscle cell apoptotic processdefinition[GO:0010667]  
1
  • Ortholog Curator
Negative regulation of DNA bindingdefinition[GO:0043392] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433] silver  
1
  • Ortholog Compara
Neural crest cell developmentdefinition[GO:0014032]  
1
  • Ortholog Curator
Noradrenergic neuron differentiationdefinition[GO:0003357]  
1
  • BHF-UCL
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Palate developmentdefinition[GO:0060021] silver  
1
  • Ortholog Compara
Peripheral nervous system neuron developmentdefinition[GO:0048935] silver  
1
  • Ortholog Compara
Positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesisdefinition[GO:2000764]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic processdefinition[GO:2000763]  
1
  • Ortholog Curator
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Regulation of secondary heart field cardioblast proliferationdefinition[GO:0003266]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Suckling behaviordefinition[GO:0001967] silver  
1
  • Ortholog Compara
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
1
  • Ortholog Compara
Thymus developmentdefinition[GO:0048538]  
1
  • Ortholog Curator
Tongue developmentdefinition[GO:0043586] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Visceral serous pericardium developmentdefinition[GO:0061032] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAND2
GenomeRNAi: 9464
PRO: PR:P61296