ISL1 - Insulin gene enhancer protein ISL-1 - human protein (Function)
 
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ISL1 »  Insulin gene enhancer protein ISL-1  (Islet-1)
 
Gene name:  ISL1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
1
  • IPIBHF-UCL
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Enhancer sequence-specific DNA bindingdefinition[GO:0001158]  
2
  • IDABHF-UCL
Estrogen receptor bindingdefinition[GO:0030331]  
  • ISSOrtholog Curator
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
  • ISSOrtholog Curator
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Atrial septum morphogenesisdefinition[GO:0060413]  
  • ISSOrtholog Curator
Axon regenerationdefinition[GO:0031103] silver  
  • IEAOrtholog Compara
Cardiac cell fate determinationdefinition[GO:0060913]  
1
  • IDABHF-UCL
Cardiac muscle cell myoblast differentiationdefinition[GO:0060379] silver  
  • IEAOrtholog Compara
Cardiac right ventricle morphogenesisdefinition[GO:0003215]  
  • ISSOrtholog Curator
Cellular response to glucocorticoid stimulusdefinition[GO:0071385]  
  • ISSOrtholog Curator
Endocardial cushion morphogenesisdefinition[GO:0003203]  
  • ISSOrtholog Curator
Innervationdefinition[GO:0060384]  
  • ISSOrtholog Curator
Mesenchymal cell differentiationdefinition[GO:0048762]  
  • ISSOrtholog Curator
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728]  
  • ISSOrtholog Curator
Negative regulation of intracellular estrogen receptor signaling pathwaydefinition[GO:0033147]  
  • ISSOrtholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Negative regulation of protein homodimerization activitydefinition[GO:0090074]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Neuron fate specificationdefinition[GO:0048665]  
  • ISSOrtholog Curator
Outflow tract morphogenesisdefinition[GO:0003151]  
  • ISSOrtholog Curator
Outflow tract septum morphogenesisdefinition[GO:0003148]  
  • ISSOrtholog Curator
Pancreas developmentdefinition[GO:0031016]  
  • ISSOrtholog Curator
Peripheral nervous system neuron axonogenesisdefinition[GO:0048936]  
  • ISSOrtholog Curator
Pharyngeal system developmentdefinition[GO:0060037]  
  • ISSOrtholog Curator
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of granulocyte colony-stimulating factor productiondefinition[GO:0071657]  
  • ISSOrtholog Curator
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
  • ISSOrtholog Curator
Positive regulation of insulin secretiondefinition[GO:0032024]  
1
  • ICBHF-UCL
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
  • ISSOrtholog Curator
Positive regulation of interleukin-1 alpha productiondefinition[GO:0032730]  
  • ISSOrtholog Curator
Positive regulation of interleukin-1 beta productiondefinition[GO:0032731]  
  • ISSOrtholog Curator
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
  • ISSOrtholog Curator
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
  • ISSOrtholog Curator
Positive regulation of macrophage colony-stimulating factor productiondefinition[GO:1901258]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
  • ISSOrtholog Curator
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517] silver  
  • IEAOrtholog Compara
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
  • ISSOrtholog Curator
Regulation of secondary heart field cardioblast proliferationdefinition[GO:0003266] silver  
  • IEAOrtholog Compara
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
  • IEAOrtholog Compara
Secondary heart field specificationdefinition[GO:0003139]  
1
  • IMPBHF-UCL
Sensory system developmentdefinition[GO:0048880]  
  • ISSOrtholog Curator
Spinal cord motor neuron cell fate specificationdefinition[GO:0021520] silver  
  • IEAOrtholog Compara
Spinal cord motor neuron differentiationdefinition[GO:0021522]  
  • ISSOrtholog Curator
Trigeminal nerve developmentdefinition[GO:0021559]  
  • ISSOrtholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
  • ISSOrtholog Curator
Visceral motor neuron differentiationdefinition[GO:0021524] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ISL1
GenomeRNAi: 3670
PRO: PR:P61371