ATP6V0D1 - V-type proton ATPase subunit d 1 - human protein (Function)
 
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ATP6V0D1 »  V-type proton ATPase subunit d 1  (V-ATPase subunit d 1)
 
Protein also known as:  V-ATPase 40 kDa accessory protein.
Gene name:  ATP6V0D1
Entry whose protein(s) existence is based on evidence at protein level
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1 25 1
GENE REF ISO

Function

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Overview 
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
Hydrogen-exporting ATPase activity, phosphorylative mechanismdefinition[GO:0008553] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cilium assemblydefinition[GO:0042384]  
  • ISSOrtholog Curator
Proton transportdefinition[GO:0015992]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+9114  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+9114  
Lysosome  hsa04142+9114  
Metabolic pathways  hsa01100+9114  
Oxidative phosphorylation  hsa00190+9114  
Phagosome  hsa04145+9114  
Rheumatoid arthritis  hsa05323+9114  
Synaptic vesicle cycle  hsa04721+9114  
Tuberculosis  hsa05152+9114  
Vibrio cholerae infection  hsa05110+9114  
According to Reactome, this protein belongs to the following pathways:
Insulin receptor recycling  REACT_1109  
Phagosomal maturation (early endosomal stage)  REACT_121256  
Transferrin endocytosis and recycling  REACT_25283  
XBP1(S) activates chaperone genes  REACT_18273  
 
More information is available from:
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V0D1
GenomeRNAi: 9114
PRO: PR:P61421