HSPE1 - 10 kDa heat shock protein, mitochondrial - human protein (Function)
 
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HSPE1 »  10 kDa heat shock protein, mitochondrial  (Hsp10)
 
Protein also known as:  Early-pregnancy factor (EPF).
Gene name:  HSPE1
Family name: GroES chaperonin
Entry whose protein(s) existence is based on evidence at protein level
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1 48 1
GENE REF ISO

Function

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Overview 
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIUniProtKB
  • ISSOrtholog Curator
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Unfolded protein bindingdefinition[GO:0051082]  
2
  • NASUniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • NASUniProtKB
Protein foldingdefinition[GO:0006457] silver  
  • IEAInterPro 2 GO
Response to unfolded proteindefinition[GO:0006986]  
1
  • TASPINC
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GroES
GenomeRNAi: 3336
PRO: PR:P61604