NPC2 - Epididymal secretory protein E1 - human protein (Function)
 
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NPC2 »  Epididymal secretory protein E1
 
Protein also known as:  Niemann-Pick disease type C2 protein.
Gene name:  NPC2
Family name: NPC2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 53 1
GENE REF ISO

Function

 show evidences
Overview 
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the resistance-nodulation-cell division (rnd) superfamily  2.A.6.6.1  
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
2
  • IDAUniProtKB
  • IDAHGNC
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Cholesterol effluxdefinition[GO:0033344]  
1
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IDAUniProtKB
Cholesterol metabolic processdefinition[GO:0008203]  
  • IEAUniProtKB KW
Cholesterol transportdefinition[GO:0030301]  
2
  • IDAUniProtKB
  • IDAHGNC
Glycolipid transportdefinition[GO:0046836]  
1
  • TASHGNC
Intracellular cholesterol transportdefinition[GO:0032367]  
3
  • IGIMGI
  • IDAUniProtKB
  • IDAHGNC
Intracellular sterol transportdefinition[GO:0032366]  
1
  • IDAHGNC
Phospholipid transportdefinition[GO:0015914]  
1
  • TASHGNC
Regulation of isoprenoid metabolic processdefinition[GO:0019747]  
1
  • TASUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+10577  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10577
PRO: PR:P61916