PPP1CB - Serine/threonine-protein phosphatase PP1-beta catalytic subunit - human protein (Function)
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PPP1CB »  Serine/threonine-protein phosphatase PP1-beta catalytic subunit   [ EC ]  (PP-1B)
Gene name:  PPP1CB
Family name: PPP phosphatase » PP-1
Entry whose protein(s) existence is based on evidence at protein level
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Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Myosin phosphatase activitydefinition[GO:0017018]  
  • ISSOrtholog Curator
Myosin-light-chain-phosphatase activitydefinition[GO:0050115]  
  • IDAUniProtKB
Phosphatase activitydefinition[GO:0016791]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
  • IPIUniProtKB
GO biological process 
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Entrainment of circadian clock by photoperioddefinition[GO:0043153]  
  • ISSOrtholog Curator
Glycogen metabolic processdefinition[GO:0005977]  
  • IEAUniProtKB KW
Protein dephosphorylationdefinition[GO:0006470]  
  • ISSOrtholog Curator
Regulation of cell adhesiondefinition[GO:0030155]  
  • IDAUniProtKB
Regulation of circadian rhythmdefinition[GO:0042752]  
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
EC [Myosin light-chain] phosphate + H(2)O [myosin light-chain] + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 manganese ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+5500  
Focal adhesion  hsa04510+5500  
Herpes simplex infection  hsa05168+5500  
Insulin signaling pathway  hsa04910+5500  
Long-term potentiation  hsa04720+5500  
Oocyte meiosis  hsa04114+5500  
Regulation of actin cytoskeleton  hsa04810+5500  
Vascular smooth muscle contraction  hsa04270+5500  
According to Reactome, this protein belongs to the following pathways:
Downregulation of TGF-beta receptor signaling  REACT_120727  
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  REACT_494  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  


Biological process 
Biological rhythms  definition   [KW-0090]
Carbohydrate metabolism  definition   [KW-0119]
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Glycogen metabolism  definition   [KW-0321]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PPP1CB
GenomeRNAi: 5500
PRO: PR:P62140