CALM1 - Calmodulin - human protein (Function)
 
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CALM1 »  Calmodulin  (CaM)
 
Gene name:  CALM1 ; CALM2 ; CALM3
Family name: Calmodulin
Entry whose protein(s) existence is based on evidence at protein level
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3 209 1
GENE REF ISO

Function

 show evidences
Overview 
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the animal calmodulin-dependent e.r. secretion pathway (csp) family  9.C.15.1.1  
GO molecular function 
Adenylate cyclase bindingdefinition[GO:0008179] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509]  
4
  • IDABHF-UCL
  • IDAMGI
  • ISSOrtholog Curator
Calcium-dependent protein bindingdefinition[GO:0048306] silver  
  • IEAOrtholog Compara
Ion channel bindingdefinition[GO:0044325]  
2
  • IPIBHF-UCL
N-terminal myristoylation domain bindingdefinition[GO:0031997]  
1
  • IPIUniProtKB
Nitric-oxide synthase bindingdefinition[GO:0050998] silver  
  • IEAOrtholog Compara
Nitric-oxide synthase regulator activitydefinition[GO:0030235] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
  • IEAOrtholog Compara
Phospholipase bindingdefinition[GO:0043274]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
30
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein phosphatase activator activitydefinition[GO:0072542]  
1
  • IDABHF-UCL
Thioesterase bindingdefinition[GO:0031996]  
1
  • IPIUniProtKB
Titin bindingdefinition[GO:0031432]  
1
  • IPIBHF-UCL
Type 3 metabotropic glutamate receptor bindingdefinition[GO:0031800] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190] silver  
  • IEAOrtholog Compara
Detection of calcium iondefinition[GO:0005513]  
1
  • IMPBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASUniProtKB
Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
  • ISSOrtholog Curator
Positive regulation of cyclic nucleotide metabolic processdefinition[GO:0030801]  
1
  • IDABHF-UCL
Positive regulation of cyclic-nucleotide phosphodiesterase activitydefinition[GO:0051343]  
1
  • IDABHF-UCL
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000] silver  
  • IEAOrtholog Compara
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516]  
1
  • IDABHF-UCL
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • IDABHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060316]  
1
  • IDABHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • IMPBHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
  • ICGO curators
Regulation of cell communication by electrical coupling involved in cardiac conductiondefinition[GO:1901844]  
  • ICGO curators
Regulation of cytokinesisdefinition[GO:0032465]  
1
  • IMPUniProtKB
Regulation of heart ratedefinition[GO:0002027]  
1
  • IMPBHF-UCL
Regulation of high voltage-gated calcium channel activitydefinition[GO:1901841] silver  
  • IEAOrtholog Compara
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0010880]  
1
  • IDABHF-UCL
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592]  
1
  • IDABHF-UCL
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Substantia nigra developmentdefinition[GO:0021762]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+805  
Alzheimer's disease  hsa05010+801  
Alzheimer's disease  hsa05010+808  
Calcium signaling pathway  hsa04020+808  
Calcium signaling pathway  hsa04020+801  
Calcium signaling pathway  hsa04020+805  
Dopaminergic synapse  hsa04728+805  
Dopaminergic synapse  hsa04728+808  
Dopaminergic synapse  hsa04728+801  
Gastric acid secretion  hsa04971+808  
Gastric acid secretion  hsa04971+801  
Gastric acid secretion  hsa04971+805  
Glioma  hsa05214+805  
Glioma  hsa05214+808  
Glioma  hsa05214+801  
GnRH signaling pathway  hsa04912+805  
GnRH signaling pathway  hsa04912+801  
GnRH signaling pathway  hsa04912+808  
Insulin signaling pathway  hsa04910+808  
Insulin signaling pathway  hsa04910+801  
Insulin signaling pathway  hsa04910+805  
Long-term potentiation  hsa04720+801  
Long-term potentiation  hsa04720+808  
Long-term potentiation  hsa04720+805  
Melanogenesis  hsa04916+808  
Melanogenesis  hsa04916+801  
Melanogenesis  hsa04916+805  
Neurotrophin signaling pathway  hsa04722+801  
Neurotrophin signaling pathway  hsa04722+805  
Neurotrophin signaling pathway  hsa04722+808  
Olfactory transduction  hsa04740+801  
Olfactory transduction  hsa04740+808  
Olfactory transduction  hsa04740+805  
Oocyte meiosis  hsa04114+808  
Oocyte meiosis  hsa04114+801  
Oocyte meiosis  hsa04114+805  
Pertussis  hsa05133+805  
Pertussis  hsa05133+801  
Pertussis  hsa05133+808  
Phosphatidylinositol signaling system  hsa04070+808  
Phosphatidylinositol signaling system  hsa04070+805  
Phosphatidylinositol signaling system  hsa04070+801  
Phototransduction  hsa04744+801  
Phototransduction  hsa04744+805  
Phototransduction  hsa04744+808  
Salivary secretion  hsa04970+801  
Salivary secretion  hsa04970+805  
Salivary secretion  hsa04970+808  
Tuberculosis  hsa05152+801  
Tuberculosis  hsa05152+805  
Tuberculosis  hsa05152+808  
Vascular smooth muscle contraction  hsa04270+808  
Vascular smooth muscle contraction  hsa04270+801  
Vascular smooth muscle contraction  hsa04270+805  
According to Reactome, this protein belongs to the following pathways:
Activation of Ca-permeable Kainate Receptor  REACT_21346  
Activation of CaMK IV  REACT_20652  
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
Ca2+ pathway  REACT_172761  
Calmodulin induced events  REACT_9000  
CaM pathway  REACT_9053  
Cam-PDE 1 activation  REACT_15408  
CaMK IV-mediated phosphorylation of CREB  REACT_15502  
CREB phosphorylation through the activation of CaMKII  REACT_20642  
CREB phosphorylation through the activation of CaMKK  REACT_20661  
DARPP-32 events  REACT_15334  
eNOS activation  REACT_12477  
FCERI mediated Ca+2 mobilization  REACT_163834  
Glycogen breakdown (glycogenolysis)  REACT_1008  
Inactivation, recovery and regulation of the phototransduction cascade  REACT_163919  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Smooth Muscle Contraction  REACT_20558  
Synthesis of IP3 and IP4 in the cytosol  REACT_150312  
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation  REACT_111176  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 
More information is available from:
Note 
This protein has four functional calcium-binding sites.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Calmodulin_1
GeneWiki: CALM3
GeneWiki: CALM2
PRO: PR:P62158