UBE2G1 - Ubiquitin-conjugating enzyme E2 G1 - human protein (Function)
 
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UBE2G1 »  Ubiquitin-conjugating enzyme E2 G1   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin carrier protein G1. Cleaved into:  Ubiquitin-conjugating enzyme E2 G1, N-terminally processed.
Gene name:  UBE2G1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IDAUniProtKB
Protein K63-linked ubiquitinationdefinition[GO:0070534]  
1
  • IDAUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Parkinson's disease  hsa05012+7326  
Protein processing in endoplasmic reticulum  hsa04141+7326  
Ubiquitin mediated proteolysis  hsa04120+7326  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBE2G1
GenomeRNAi: 7326
PRO: PR:P62253