ESRRG - Estrogen-related receptor gamma - human protein (Function)
 
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Protein
Gene
References

 
ESRRG »  Estrogen-related receptor gamma
 
Protein also known as:  Nuclear receptor subfamily 3 group B member 3.
Gene name:  ESRRG
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.  
5
  • UniProtKB
GO molecular function 
AF-2 domain bindingdefinition[GO:0050682]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Retinoic acid receptor activitydefinition[GO:0003708] silver  
1
  • InterPro 2 GO
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228] silver  
1
  • Ortholog Compara
Steroid bindingdefinition[GO:0005496] silver  
1
  • InterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Retinoic acid receptor signaling pathwaydefinition[GO:0048384] silver  
1
  • InterPro 2 GO
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
Note 
No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Estrogen-related_receptor_gamma
GenomeRNAi: 2104
PRO: PR:P62508
Chemistry
GuidetoPHARMACOLOGY: 624