ACTA2 - Actin, aortic smooth muscle - human protein (Function)
 
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ACTA2 »  Actin, aortic smooth muscle
 
Protein also known as:  Cell growth-inhibiting gene 46 protein.
Gene name:  ACTA2
Family name: Actin
Entry whose protein(s) existence is based on evidence at protein level
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1 78 1
GENE REF ISO

Function

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Overview 
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GO biological process 
Glomerular mesangial cell developmentdefinition[GO:0072144]  
1
  • IEPUniProtKB
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Vascular smooth muscle contractiondefinition[GO:0014829] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+59  
According to Reactome, this protein belongs to the following pathway:
Muscle contraction  REACT_17044  
Note 
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACTA2
GenomeRNAi: 59
PRO: PR:P62736