GNB1 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 - human protein (Function)
 
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GNB1 »  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
 
Protein also known as:  Transducin beta chain 1.
Gene name:  GNB1
Entry whose protein(s) existence is based on evidence at protein level
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1 67 2
GENE REF ISO

Function

 show evidences
Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
1
  • CuratedUniProtKB
GO molecular function 
GTPase activitydefinition[GO:0003924]  
1
  • IDAMGI
GTPase bindingdefinition[GO:0051020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAMGI
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191]  
  • ISSOrtholog Curator
Cardiac muscle cell apoptotic processdefinition[GO:0010659] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular response to catecholamine stimulusdefinition[GO:0071870]  
  • ISSOrtholog Curator
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to prostaglandin E stimulusdefinition[GO:0071380]  
  • ISSOrtholog Curator
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
1
  • TASPINC
GTP catabolic processdefinition[GO:0006184]  
2
  • IDAGOC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASPINC
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Sensory perception of tastedefinition[GO:0050909] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2782  
Cholinergic synapse  hsa04725+2782  
Dopaminergic synapse  hsa04728+2782  
GABAergic synapse  hsa04727+2782  
Glutamatergic synapse  hsa04724+2782  
Phototransduction  hsa04744+2782  
Taste transduction  hsa04742+2782  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Activation of the phototransduction cascade  REACT_163932  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
ADP signalling through P2Y purinoceptor 12  REACT_20653  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Ca2+ pathway  REACT_172761  
G alpha (12/13) signalling events  REACT_18407  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
G beta:gamma signalling through PLC beta  REACT_19145  
G-protein activation  REACT_15457  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
Inactivation, recovery and regulation of the phototransduction cascade  REACT_163919  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Olfactory Signaling Pathway  REACT_15488  
Presynaptic function of Kainate receptors  REACT_21254  
Prostacyclin signalling through prostacyclin receptor  REACT_23946  
Regulation of water balance by renal Aquaporins  REACT_24023  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNB1
GenomeRNAi: 2782
PRO: PR:P62873